Suggestions for the assessment of the allergenic potential of genetically modified organisms
Identifieur interne : 00A424 ( Main/Exploration ); précédent : 00A423; suivant : 00A425Suggestions for the assessment of the allergenic potential of genetically modified organisms
Auteurs : Armin Spök [Autriche] ; Helmut Gaugitsch [Autriche] ; Sylvia Laffer [Autriche] ; Gabrielle Pauli [France] ; Hirohisa Saito [Japon] ; Hugh Sampson [États-Unis] ; Elopy Sibanda [Zimbabwe] ; Wayne Thomas [Australie] ; Marianne Van Hage [Suède] ; Rudolf Valenta [Autriche]Source :
- International archives of allergy and immunology [ 1018-2438 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Allergie, Organisme génétiquement modifié.
English descriptors
- KwdEn :
Abstract
The prevalence of allergic diseases has been increasing continuously and, accordingly, there is a great desire to evaluate the allergenic potential of components in our daily environment (e.g., food). Although there is almost no scientific evidence that genetically modified organisms (GMOs) exhibit increased allergenicity compared with the corresponding wild type significant concerns have been raised regarding this matter. In principle, it is possible that the allergenic potential of GMOs may be increased due to the introduction of potential foreign allergens, to potentially upregulated expression of allergenic components caused by the modification of the wild type organism or to different means of exposure. According to the current practice, the proteins to be introduced into a GMO are evaluated for their physiochemical properties, sequence homology with known allergens and occasionally regarding their allergenic activity. We discuss why these current rules and procedures cannot predict or exclude the allergenicity of a given GMO with certainty. As an alternative we suggest to improve the current evaluation by an experimental comparison of the wild-type organism with the whole GMO regarding their potential to elicit reactions in allergic individuals and to induce de novo sensitizations. We also recommend that the suggested assessment procedures be equally applied to GMOs as well as to natural cultivars in order to establish effective measures for allergy prevention.
Affiliations:
- Australie, Autriche, France, Japon, Suède, Zimbabwe, États-Unis
- Alsace (région administrative), Grand Est, Région de Kantō, Svealand, Vienne (Autriche)
- Stockholm, Strasbourg, Tokyo, Vienne (Autriche)
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Le document en format XML
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Spök</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inter-University Research Centre for Technology, Work, and Culture</s1><s2>Graz</s2><s3>AUT</s3><sZ>1 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Gaugitsch, Helmut" sort="Gaugitsch, Helmut" uniqKey="Gaugitsch H" first="Helmut" last="Gaugitsch">Helmut Gaugitsch</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Austrian Federal Environment Agency, Medical University of Vienna</s1><s2>Vienna</s2><s3>AUT</s3><sZ>2 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Laffer, Sylvia" sort="Laffer, Sylvia" uniqKey="Laffer S" first="Sylvia" last="Laffer">Sylvia Laffer</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Pathophysiology, 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Saito</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>National Research Institute for Child Health and Development</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>5 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Sampson, Hugh" sort="Sampson, Hugh" uniqKey="Sampson H" first="Hugh" last="Sampson">Hugh Sampson</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>mount Sinai School of Medicine</s1><s2>New York, N.Y</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>mount Sinai School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Sibanda, Elopy" sort="Sibanda, Elopy" uniqKey="Sibanda E" first="Elopy" last="Sibanda">Elopy Sibanda</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Immunology, University of Zimbabwe College of Medicine</s1><s2>Harare</s2><s3>ZWE</s3><sZ>7 aut.</sZ></inist:fA14><country>Zimbabwe</country><wicri:noRegion>Harare</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Wayne" sort="Thomas, Wayne" uniqKey="Thomas W" first="Wayne" last="Thomas">Wayne Thomas</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>TVW Telethon Institute for Child Health Research</s1><s2>Perth</s2><s3>AUS</s3><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>TVW Telethon Institute for Child Health Research</wicri:noRegion></affiliation></author><author><name sortKey="Van Hage, Marianne" sort="Van Hage, Marianne" uniqKey="Van Hage M" first="Marianne" last="Van Hage">Marianne Van Hage</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute and University Hospital</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Valenta, Rudolf" sort="Valenta, Rudolf" uniqKey="Valenta R" first="Rudolf" last="Valenta">Rudolf Valenta</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna</s1><s2>Vienna</s2><s3>AUT</s3><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author></analytic><series><title level="j" type="main">International archives of allergy and immunology</title><title level="j" type="abbreviated">Int. arch. allergy immunol.</title><idno type="ISSN">1018-2438</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International archives of allergy and immunology</title><title level="j" type="abbreviated">Int. arch. allergy immunol.</title><idno type="ISSN">1018-2438</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Allergen</term><term>Allergy</term><term>Genetically modified organism</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Allergie</term><term>Organisme génétiquement modifié</term><term>Allergène</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Allergie</term><term>Organisme génétiquement modifié</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The prevalence of allergic diseases has been increasing continuously and, accordingly, there is a great desire to evaluate the allergenic potential of components in our daily environment (e.g., food). Although there is almost no scientific evidence that genetically modified organisms (GMOs) exhibit increased allergenicity compared with the corresponding wild type significant concerns have been raised regarding this matter. In principle, it is possible that the allergenic potential of GMOs may be increased due to the introduction of potential foreign allergens, to potentially upregulated expression of allergenic components caused by the modification of the wild type organism or to different means of exposure. According to the current practice, the proteins to be introduced into a GMO are evaluated for their physiochemical properties, sequence homology with known allergens and occasionally regarding their allergenic activity. We discuss why these current rules and procedures cannot predict or exclude the allergenicity of a given GMO with certainty. As an alternative we suggest to improve the current evaluation by an experimental comparison of the wild-type organism with the whole GMO regarding their potential to elicit reactions in allergic individuals and to induce de novo sensitizations. We also recommend that the suggested assessment procedures be equally applied to GMOs as well as to natural cultivars in order to establish effective measures for allergy prevention.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>France</li><li>Japon</li><li>Suède</li><li>Zimbabwe</li><li>États-Unis</li></country><region><li>Alsace (région administrative)</li><li>Grand Est</li><li>Région de Kantō</li><li>Svealand</li><li>Vienne (Autriche)</li></region><settlement><li>Stockholm</li><li>Strasbourg</li><li>Tokyo</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><noRegion><name sortKey="Spok, Armin" sort="Spok, Armin" uniqKey="Spok A" first="Armin" last="Spök">Armin Spök</name></noRegion><name sortKey="Gaugitsch, Helmut" sort="Gaugitsch, Helmut" uniqKey="Gaugitsch H" first="Helmut" last="Gaugitsch">Helmut Gaugitsch</name><name sortKey="Laffer, Sylvia" sort="Laffer, Sylvia" uniqKey="Laffer S" first="Sylvia" last="Laffer">Sylvia Laffer</name><name sortKey="Valenta, Rudolf" sort="Valenta, Rudolf" uniqKey="Valenta R" first="Rudolf" last="Valenta">Rudolf Valenta</name></country><country name="France"><region name="Grand Est"><name sortKey="Pauli, Gabrielle" sort="Pauli, Gabrielle" uniqKey="Pauli G" first="Gabrielle" last="Pauli">Gabrielle Pauli</name></region></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Saito, Hirohisa" sort="Saito, Hirohisa" uniqKey="Saito H" first="Hirohisa" last="Saito">Hirohisa Saito</name></region></country><country name="États-Unis"><noRegion><name sortKey="Sampson, Hugh" sort="Sampson, Hugh" uniqKey="Sampson H" first="Hugh" last="Sampson">Hugh Sampson</name></noRegion></country><country name="Zimbabwe"><noRegion><name sortKey="Sibanda, Elopy" sort="Sibanda, Elopy" uniqKey="Sibanda E" first="Elopy" last="Sibanda">Elopy Sibanda</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Thomas, Wayne" sort="Thomas, Wayne" uniqKey="Thomas W" first="Wayne" last="Thomas">Wayne Thomas</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Van Hage, Marianne" sort="Van Hage, Marianne" uniqKey="Van Hage M" first="Marianne" last="Van Hage">Marianne Van Hage</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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